Montrose defender Alan Campbell suffered a fractured cheekbone when these two sides met at the weekend and he misses out for the visitors.
Sean Crichton and fellow centre-half Gordon Pope are also unavailable for Steven Tweed's side.
Annan Athletic manager Harry Cairney: "Another win would take us closer to matching the points target we achieved in our first season in the SFL.
"And that is our target between now and the final game."
Montrose manager Steven Tweed: "We have four games left to get off the bottom of the table.
"If we are to win this one, we have to start a lot better than we did at the weekend."
Source: BBC Sport
Source: BBC Sport